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Date of Issue : Dec 1998 1. IDENTIFICATION
General Product Name : IBUPROFEN Other Names : 2-(4-ISOBUTYLPHENYL)PROPIONIC ACID 4-ISOBUTYLHYDRATROPIC ACID UN No. : N/A Dangerous Goods Class : None Allocated Subsidiary Risk : None Allocated Hazchem Code : N/A Pack Group : 0 EPG : N/A Poisons Schedule : 4 Uses : Ingredient in over the counter pain relievers.
1.1 Physical Description / Properties
Appearance : White crystalline powder. Formula : C13H18O2 Boiling Point : N/A deg C Melting Point : 75 deg C Vapour Pressure : N/A Specific Gravity : N/A (water = 1) Flash Point : N/A pH : N/A () Solubility in water : N/A g/l (25 deg C) Flammability Limits (as percentage volume in air) Lower Explosion Limit : N/A Upper Explosion Limit : N/A 1.2 Other Properties
pKa = 4.54 Ignition energy = 7 mJ Log P (octanol/water) = 3.30 at pH 5 Solubility in water = 0.107g/l at pH 5 ; 15.8g/l at pH 7 Solubility in other solvents : readily soluble in most organic solvents 1.3 Ingredients
2. HEALTH HAZARD INFORMATION
2.1 Health Effects - Acute Swallowed
Harmful if swallowed. Eye
Irritating to the eyes. Skin
May be irritating to the skin. Inhaled
Irritating to the respiratory system. 2.2 Health Effects - Chronic
No data available
2.3 First Aid
Swallowed
Wash out mouth thoroughly with water. DO NOT induce vomiting. Give sips of water to drink. Obtain medical attention.
Eye
Immediately irrigate with water for at least 10 minutes. Obtain medical attention.
Skin
Remove contaminated clothing. Wash the affected skin with water or soap and water. If persistent irritation develops obtain medical attention.
Inhaled
Remove to fresh air. If recovery is not complete obtain medical attention.
First Aid Facilities
Ensure an eye bath and safety shower are available and ready for use.
2.5 Advice to Doctor
Treat symptomatically based on judgement of doctor and individual reactions of patient.
2.6 Toxicity Data
Oral LD50 = 800 mg/kg (Mouse) ; 1600 mg/kg (Rat) Intraperitoneal LD50 = 320 mg/kg (Mouse) Subcutaneous LD50 = 1300 mg/kg (Rat) Inhalation LC50 = not available Not carcinogenic in a 80 week feeding study in mice and a 2-year feeding study in rats. Not teratogenic in mice, rats and rabbits. Not cytogenetic against human lymphocytes in vivo. Not a bacterial mutagen in vitro.
3. PRECAUTIONS FOR USE
3.1 Exposure Standards
An exposure standard has not been established for this material by Worksafe . The manufacturer of this material recommends a workplace exposure level of 5 mg/m3.
3.2 Engineering Controls
Ensure adequate ventilation to maintain airborne concentrations below applicable workplace standards. Use mechanical local exhaust ventilation where possible.
3.3 Personal Protection
Wear an approved particulate respirator, PVC or rubber gloves, chemical safety goggles and overalls or disposable coveralls. Wash hands and face thoroughly after handling and before work breaks, eating, drinking, smoking and using toilet facilities.
3.4 Flammability
Will burn when exposed to heat or flame. SAFE HANDLING INFORMATION
4.1 Storage / Transport
Ensure good ventilation where used. Take precautions against static discharge. Provide dust explosion protection, eg. explosion suppression or explosion venting. Store in original containers at ambient temperature, and away from oxidising materials, heat and sources of ignition, food, drink and animal feedstuffs.
4.2 Packaging / Labelling UN No. N/A Class None Allocated Sub Risk None Allocated Hazchem Code N/A Pack Group 0 EPG No. N/A Shipping Name IBUPROFEN Hazard HARMFUL
Risk Phrases R22 Harmful if swallowed. R36/37 Irritating to eyes and respiratory system. R51 Toxic to aquatic organisms. R53 May cause long term adverse effects in the aquatic environment.
Safety Phrases S26 In case of contact with eyes, rinse immediately with plenty of water and contact a doctor or . S57 Use appropriate containment to avoid environmental contamination. S60 This material and its container must be disposed of as hazardous waste.
4.3 Spills and Disposal
Spills
Clean-up personnel should wear full protective clothing including breathing protection in dusty areas. Prevent entry into surface waters, drains and/or watercourses.
Immediately vacuum or sweep up (avoid creating a dust cloud). Transfer to a suitable salvage container for subsequent correct disposal. Clean the spillage site to foul water drain with detergent and water.
Disposal
Dispose of in accordance with all Local, State and Federal regulations at an approved waste disposal facility by high temperature incineration.
4.4 FIRE AND EXPLOSION HAZARD Fire / Explosion
Stable at normal temperatures. Combustible. Weak to moderate explosion hazard. Avoid heat and sources of ignition, and oxidising materials. Hazardous decomposition products include acrid smoke and fumes.
Extinguishing Media
Fire-fighters should wear full protective clothing including self-contained breathing apparatus. Use carbon dioxide, dry chemical powder, alcohol foam, or water mist type extinguishers. 5 OTHER INFORMATION
Other Information
Toxic to daphnia. May cause long-term effects in the aquatic environment. EC50 Daphnia magna (water flea) : 9.06-11.5 mg/l/48hrs LC50 Lepomis machrochirus (bluegill sunfish) : 173 mg/l/96hrs LC50 Mysidopsis bahia (mysid) : >100 mg/l/96hrs LC50 Cyprinodon variegatus (sheepshead minnow) : >300 mg/l/96hrs IC50 Selenastrum capricomutum (freshwater green algae) : >30 mg/l/96hrs IC50 Skeletonema costatum (saltwater diatom) : 7.1 mg/l/96hrs EC50 Microtox (R) : 12.30 mg/l/5mins Not considered readily biodegradable in Sturn Test (OECD 301B) for the determination of biodegradability by the measurement of CO2 evolution.
5.1 Contact Points
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The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
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