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Date of Issue : Sep 2000 1. IDENTIFICATION
General Product Name : METHYL ETHYL KETOXIME Other Names : MEK-OXIME METHYL ETHYL KETOXIME; 2-BUTANONE OXIME UN No. : N/A Dangerous Goods Class : C.1 Subsidiary Risk : None Allocated Hazchem Code : N/A Pack Group : 0 EPG : 14 Poisons Schedule : N/A Uses : Primarily used as an antiskinning agent in alkyd paints. Also used as a blocking agent for urethane polymers and as a corrosion inhibitor in boilers.
1.1 Physical Description / Properties
Appearance : Clear, colourless to light yellow liquid; odour varies from a hardly discernable ethereal aroma to an unpleasant aroma. Formula : CH3C:NOHCH2CH3 Boiling Point : 152 deg C Melting Point : -29.5 deg C Vapour Pressure : <1.07 mm Hg (1 atmosphere) Specific Gravity : 0.92 (water = 1) Flash Point : Open Cup 69 pH : N/A () Solubility in water : N/A g/l (25 deg C) Flammability Limits (as percentage volume in air) Lower Explosion Limit : 1.5 Upper Explosion Limit : 5.3 1.2 Other Properties
Slightly soluble in water. Soluble in alcohol, ether. 1.3 Ingredients
2. HEALTH HAZARD INFORMATION
2.1 Health Effects - Acute Swallowed
Considered an unlikely route of entry in commercial/industrial environments. The liquid is irritating and may be harmful if swallowed. Ingestion may result in nausea, pain and vomiting. Vomit entering the lungs by aspiration may cause potentially lethal chemical pneumonitis. Eye
The liquid is extremely irritating to the eyes and is capable of causing pain and severe conjunctivitis. Corneal injury may develop, with possible permanent impairment of vision, if not promptly and adequately treated. 0.1 ml of MEKO was corrosive to the rabbit eye. Skin
The liquid is irritating to the skin and is capable of causing allergic skin reactions. Open cuts, abraded or irritated skin should not be exposed to this material. The material may accentuate any pre-existing skin condition. Application of 0.5mg MEKO to the backs of rabbits for 24 hours under an occlusive dressing produced mild irritation (Draize score 1.5 out of 8). MEKO was a strong sensitiser in the maximisation test (8 out of 10 guinea pigs were sensitised). Inhaled
The vapour is irritating to the upper respiratory tract. The principal toxic effects of MEKO in animal studies, regardless of the route of administration, include haemolytic anaemia, increased respiration; and reversible reduction in spontaneous activity, motor coordination and muscle tone. At high vapour concentrations the product has a reversible narcotic action. Extremely high concentrations may lead to coma and respiratory failure. Central vervous (CNS) depression may be evidient early. Symptoms of moderate poisoning may include giddiness, headache, dizziness and nausea. Serious poisonings may result in respiratory depression and may be fatal. 2.2 Health Effects - Chronic
Princiapl routes of exposure are by accidental skin and eye contact and by inhalation of vapours especially at higher temperatures. MEKO administered to rats cby gavage at 25. 75 and 225 mg/kg/day, 7 days/week for 13 weeks, produced dose-related decreases in red blood cell counts and haemoglobin and haemotocrit values accompanied by a mild to marked reticulocytosis (increased no. of young red blood cells). Other effects included a dose-related pattern of spleen, liver and kidney weights. The liver and spleen showed evidnece of compensatory red blood cell production suggesting that, in the rat, MEKO induces haemolytic anaemia with complementary erythropoiesis. A no-observed-effect-level was not established but effects at 25 mg/kg were described as minimal. When MEKO was administered to rats at dose levels of 0.5, and 1.0 mg/kg/day, daily for 4 weeks, transient central nervous system depression immediately followed. At 4 weeks dose-related decreases were seen in red blood cell count and haemoglobin. Dose-related increases were evident in spleen weight (from 1.7 to 3.2 fold). It was concluded that
2.3 First Aid
Swallowed
If conscious, give water (or milk) to drink. INDUCE vomiting with IPECAC SYRUP, orfingers down the back of the throat, ONLY IF CONSCIOUS. Transport to hospital, or doctor, without delay.
Eye
Immediately hold eyes open and wash continuously with running water for at least 15 minutes. Ensure irrigation under eyelids. Seek medical attention without delay.
Skin
If product comes in contact with the skin: Immediately remove all contaminated clothing, including footwear (after rinsing with water). Wash affected areas with water (and soap if available). Seek medical attention in event of irritation.
Inhaled
If fumes or combustion products are inhaled: Remove to fresh air. Lay patient down. Keep warm and rested. If available, administer medical oxygen by traned personnel. If breathing is shallow or has stopped, ensure clear airway and apply resuscitation. Transport to hospital, or doctor, without delay.
First Aid Facilities
Ensure an eye bath and safety shower available and ready for use.
2.5 Advice to Doctor
Treat symptomatically based on individual reactions of patient and judgement of doctor. Animal studies indicate that MEKO is rapidly hydrolysed to methyl ethyl ketone and enter the 2-carbon pool (tricarboxylic acid).
2.6 Toxicity Data
Oral (rat) LD50: 930 mg/kg. Oral (mouse) LD50: 1 g/kg. Skin (rabbit) LD50: 200 ul/kg. Target organs: Liver (tumors), Tumorigenic (carcinogenic by RTECS criteria), Tumorigenic (equivocal tumorigenic agent by RTECS criteria).
3. PRECAUTIONS FOR USE
3.1 Exposure Standards
No exposure limits set by NOHSC or ACGIH. CEL TWA: 10 ppm, 36 mg/m3 (compare WEEL-TWA). Saturated vapour concentration: 1935 ppm @ 20 deg C. MEKO produces haemolytic anaemia in animals regardless of the route of exposure. Higher doses produce transient central nervous system depression. In the absence of chronic data and because minimal effects were seen at 25mg/kg in a 13 week oral study in rats, a workplace environmental exposure level (WEEL) of 10 ppm has been proposed by the AIHA. One industrial hygiene study' indicated that MEKO exposures during use of alkyd paints are less than 1 ppm, although they reach 2 ppm when using a roller. With brush application and some ventilation, the average level was 0.3 - 0.4 ppm: with spraying it was 0.3 - 0.8 ppm.
3.2 Engineering Controls
General exhaust is adequate under normal operating conditions. Local exhaust ventilation may be required in specific circumstances. If risk of overexposure exists, wearv SAA approved respirator. Correct fit is essential to obtain adequate protection. Provide adequate ventilation in warehouse or closed storage areas.
3.3 Personal Protection
Use chemical goggles, safety glasses, DO NOT wear contact lenses (contact lenses pose a special hazard; soft lenses may absorb irritants and all lenses concentrate them). Wear impervious (rubber) gloves, safety footwear. Where concentration of gas/particulates in the breathing zone approaches or exceeds the exposure standard, respiratory protection is required. Degree of protection varies with both face-piece and Class of filter, the nature of protection variesw with the filter. For lower levels of protection use a half-face respirator (AUS P), or a powered air respirator (PAPR-AUS P). For medium levels of protection use full-face respirator (AUS P). For high levels of protection use a full-face repirator (2 P), or a powered air repsirator (PAPR 2 P). The local concentrations of material, quantity and conditions of use determine the type of personnel protective equipment required.
3.4 Flammability
Combustible liquid. SAFE HANDLING INFORMATION
4.1 Storage / Transport
Keep away from strong acids, strong oxidants and alkalis. Distillation with acid impurities may cause violent explosion. Hydrolysis with aqueous sulfuric acid followed by release of 2-butanone during distillation, left a residue of hydroxyammonium sulfate which decomposed violently. Store away from sources of heat or igntion/maked lights. Store in a well ventilated area. Store in an upright position. DO NOT sotre near acids, or oxidizing agents. Keep containers securely sealed. Check regularly for spills and leaks. Protect containers against physical damage.
4.2 Packaging / Labelling UN No. N/A Class C.1 Sub Risk None Allocated Hazchem Code N/A Pack Group 0 EPG No. 14 Shipping Name METHYL ETHYL KETOXIME Hazard IRRITANT
Risk Phrases R36 Irritating to eyes. R43 May cause sensitisation by skin contact.
Safety Phrases S23 Do not breathe vapour. S24 Avoid contact with skin. S2 Keep out of the reach of children.
4.3 Spills and Disposal
Spills
Clean up personnel should wear full protective clothing including respiratory protection. Remove all sources of igntion. If large quantity has been spilled alert the Fire Bridage and tell them the location and nature of the hazard. Clear area of personnel. Shut of all possible sources of ignition and increase ventilation. Stop leak if safe to do so. Do not allow spilled material to enter waterways.
For small spills - wipe up and absorb with vermiculate or other absorbent material. Place spilled material in clean, dry, sealable, labelled container. For large spills - absorb or cover spill with sand, earth, inert material or vermiculate. Collect recoverable product into labelled containers for recycling. Collect residues and seal in labelled drum for disposal. Wash spill site with large quantities of water.
Disposal
Recycle wherever possible. Consult manufacturer for recycling options. Dispose according to all Local, State and Federal regulations. Recycle containers wherever possible, otherwise dispose of in an authorised landfill.
4.4 FIRE AND EXPLOSION HAZARD Fire / Explosion
Combustible. Slight fire hazard when exposed to heat of flame. Heating may cause expansion or decomposition leading to violent rupture of containers. On combustion, may emit toxic fumes of carbon monoxide (CO). May emit acrid smoke. Other combustion products include nitrogen oxides (NOx). Decomposes on heating and produces methyl ethyl ketone and substituted amides.
Extinguishing Media
Fireifighters should wear full protective clothing including self contained breathing appratus. Use water spray, carbon dioxide, dry chemical or appropriate foam as extinguishing media. Combustible liquid. 5 OTHER INFORMATION
Other Information
Thermal decomposition yields methyl ethyl ketone and substituted amides.
5.1 Contact Points
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The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
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