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Date of Issue : Mar 2000 1. IDENTIFICATION
General Product Name : DL-METHIONINE Other Names : 2-AMINO-4-(METHYLTHIO)BUTYRIC ACID UN No. : N/A Dangerous Goods Class : None Allocated Subsidiary Risk : None Allocated Hazchem Code : N/A Pack Group : 0 EPG : N/A Poisons Schedule : N/A Uses : Pharmaceuticals, feed additive, vegetable oil enrichment, single-cell protein.
1.1 Physical Description / Properties
Appearance : Colourless to weak light brown crytsalline solid with distinct odour. Formula : C5H11NO2S Boiling Point : N/A deg C Melting Point : >266 deg C Vapour Pressure : N/A Specific Gravity : N/A (water = 1) Flash Point : N/A pH : 5-6 (100g/l H2O @ 20 degC) Solubility in water : 30 g/l (25 deg C) Flammability Limits (as percentage volume in air) Lower Explosion Limit : N/A Upper Explosion Limit : N/A 1.2 Other Properties
Melting point: 266 - 267 deg C (decomposes). Burns out with flames or shower of sparks. Ignition temperature: 320 deg C. Dust explosive, class ST1. Apparent bulk density: 680 kg/m3. Partition coefficient: log POW 1.28. 1.3 Ingredients
2. HEALTH HAZARD INFORMATION
2.1 Health Effects - Acute Swallowed
May be harmful by ingestion. Eye
May cause irritation to eyes. Skin
May be harmful by skin absorption. May cause skin irritation. Inhaled
May be harmful by inhalation. 2.2 Health Effects - Chronic
No information available.
2.3 First Aid
Swallowed
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
Eye
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes. Call a physician.
Skin
In case of contact, immediately wash skin with soap and copious amounts of water. Wash contaminated clothing before reuse.
Inhaled
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
First Aid Facilities
Ensure an eye bath and safety shower available and ready for use.
2.5 Advice to Doctor
Treat symptomatically based on individual reactions of patient and judgement of doctor.
2.6 Toxicity Data
Oral (rat) LD50: >10000 mg/kg. Oral (mouse) LD50: >10000 mg/kg.
3. PRECAUTIONS FOR USE
3.1 Exposure Standards
Dust - OES (GB) : 5 mg/m3 - respirable dust. OES (GB) : 10 mg/m3 - total inhalable dust. TLV/TWA (USA) : 10 mg/m3.
3.2 Engineering Controls
Ensure suitable suction/aeration at the work place and with operation machinery. Ensure adequate ventilation to keep airbourne concentrations below the exposure standard. Mechanical exhaust required.
3.3 Personal Protection
Wear protective gloves, safety goggles with side shields, and respiratory protection if risk of inhalation of dust.
3.4 Flammability
Combustible. Dust explosion class ST1. Combustiblity test in accordance with VDI 2263: BZ 5 - burns out with flames or showers of sparks. SAFE HANDLING INFORMATION
4.1 Storage / Transport
Explosion proof installations required. Keep away from sources of ignition - do not smoke. Avoid formation of dust. Store in a cool and dry place. Avoid direct sunlight. Keep containers tightly closed when not in use. Keep away from strong oxidizers.
4.2 Packaging / Labelling UN No. N/A Class None Allocated Sub Risk None Allocated Hazchem Code N/A Pack Group 0 EPG No. N/A Shipping Name DL-METHIONINE Hazard
Risk Phrases
Safety Phrases S22 Do not breathe dust. S24/25 Avoid contact with skin and eyes.
4.3 Spills and Disposal
Spills
Clean up personnel should wear full protective clothing including respiratory protection if risk of inhalation of dust. Avoid raising dust.
Sweep up spilled material and transfer to suitable containers for later disposal. After pickup complete, ventilate area and wash spill site.
Disposal
Can be burned in suitable incineration plants or disposed of in accordance with the regulations issued by the appropriate local authorities. Bring decontaminated packaging to local recycling centre.
4.4 FIRE AND EXPLOSION HAZARD Fire / Explosion
Combustible - the following fumes may be evolved in case of fire - hydrocyanic acid, flammable smouldering gases, NOx, and sulphur oxides.
Extinguishing Media
Fire-fighters should wear full protective clothing including self-contained breathing apparatus. In case of fire use water spray, carbon dioxide, quenching foam, mist or appropriate foam. 5 OTHER INFORMATION
Other Information
Degradation (14 days): 85% - easily bidegradable. Bioaccumulation: low (log POW: 1.28). Bacteria toxicity: inhibition of respiratory activity of activated slidge at 8000 mg/l. LC50 (brachydanio rerio): >3200 mg/l/96hr. NOEC (leuciscus idus melanotus): >5000 mg/l/96hr. Behaviour in water treatment plants: Adapted - easily biodegradable. Pseudomonas putida, initial inhibition of cell multiplication at 2000 mg/l evaluation of water pollutive substances UBA. BOD5 value: 48%.
5.1 Contact Points
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The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
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